Former Grey’s Anatomy alum Sarah Drew opens up on her acrimonious departure from the show, revealing how she felt the decision was unfair. Shonda Rhimes’ ABC medical drama debuted in 2009 and has become a pop culture behemoth, running 21 seasons and 433 episodes, with 39 Primetime Emmy Award nominations. Drew joined the cast in 2009, making her debut as Dr. April Kepner in the season 6 episode “Invasion” before leaving the show after the conclusion of season 14 when the Grey’s Anatomy character got married and resigned to provide medical care to Seattle’s homeless.