Throughout its eight-season run, Monk featured many surprising guest stars, including one of the series’ best villains. The procedural format of the series created a new case for Adrian Monk (Tony Shalhoub) to solve in every episode, which enabled a wide range of characters to be introduced. Some of Monk‘s most famous guest stars were Snoop Dogg, Stanley Tucci, Sarah Silverman, and Danny Trejo, not to mention names who were yet to have their breakout roles like Jennifer Lawrence.